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Effective Steroids Powder Androstenedione CAS 63-05-8 USP Standard
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1.Basic view :
Product Name: Androstenedione
CAS: 63-05-8
MF: C19H26O2
MW: 286.41
Purity: 98.88%
Characters: Near white crystalline powder, soluble in ethanol, insoluble in water
Uses: Simplified hormone drugs, from the testis or urine extracted with the role of a male hormone steroids, norethisterone, testosterone propionate in the middle body,is widely used in small rheumatoid arthritis, diuretic, and a variety of contraceptive to control infectious inflammation.
2.Description:
4-Androstenedione can be synthesized in one of two ways. The primary pathway involves conversion of 17-hydroxypregnenolone to dehydroepiandrosterone by way of 17,20-lyase, with subsequent conversion of dehydroepiandrosterone to 4-Androstenedione via the enzyme 3-β-hydroxysteroid dehydrogenase. The secondary pathway involves conversion of 17-hydroxyprogesterone, most often a precursor to cortisol, to 4-androstenedione directly by way of 17,20-lyase. Thus, 17,20-lyase is required for the synthesis of 4-androstenedione, whether immediately or one step removed.
The production of adrenal 4-Androstenedione is governed by ACTH, whereas production of gonadal 4-Androstenedione is under control by gonadotropins. In premenopausal women, the adrenal glands and ovaries each produce about half of the total 4-androstenedione. After menopause, 4-androstenedione production is about halved, due primarily to the reduction of the steroid secreted by the ovary. Nevertheless, 4-androstenedione is the principal steroid produced by the postmenopausal.
3.Product Effect:
4-Androstenedione has been shown to increase serum testosterone levels over an eight-hour period in men when taken as a single oral dose of 300 mg per day, but a dose of 100 mg had no significant effect on serum testosterone. However, serum levels of estradiol increased following both the 100 mg and 300 mg doses. The study also reported that the serum level of estrogens and testosterone produced varied widely between individuals.
Because androstenedione can be converted to estrogenic steroids, people taking this supplement may have estrogenic side-effects.4-Androstenedione is further converted to either testosterone or estrogen. In child development, higher levels of androstenedione in boys have been associated with higher levels of acting out behaviors.
In males, conversion of androstenedione to testosterone requires the enzyme 17β-hydroxysteroid dehydrogenase.In females, androstenedione is released into the blood by theca cells. Conversion of androstenedione to estrogen (e.g., estrone and estradiol) requires the enzyme aromatase. Androstenedione is a substrate for estrogen production in granulosa cells which produce aromatase. Thus, theca cells and granulosa cells work together to form estrogens.Used for simplified hormone drugs, from the testis or urine extracted with the role of a male hormone steroid, norethisterone, testosterone propionate in the middle body, is widely used in small rheumatoid arthritis, diuretic, and a variety of contraceptive to control infectious inflammation.
