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1.Basic View:
Product Name: Tesamorelin
Specification :2 mg/vial
CAS: 804475-66-9
MF:C211H366N72O67S1
MW:5135.89
Appearance: white powder
Purity (HPLC) : ≥98%
2.Brief Introduction:
Tesamorelin is a synthetic peptide consisting of all 44 amino acids of hGRF with the addition of a trans-3-Hexenoic acid group. Tesamorelin (also known as Egrifta) is a synthetic form of growth-hormone-releasing hormone which is used in the treatment of HIV-associated lipodystrophy.tendon fibroblasts in a dose-dependent manner as revealed by transwell filter migration assay. BPC 157 also dose dependently accelerated the spreading of tendon fibroblasts on culture dishes.
The F-actin formation as detected by FITC-phalloidin staining was induced in BPC 157-treated fibroblasts. The protein expression and activation of FAK and paxillin were determined by Western blot analysis, and the phosphorylation levels of both FAK and paxillin were dose dependently increased by BPC 157 while the total amounts of protein was unaltered. In conclusion, BPC 157 promotes the ex vivo outgrowth of tendon fibroblasts from tendon explants, cell survival under stress, and the in vitro migration of tendon fibroblasts, which is likely mediated by the activation of the FAK-paxillin pathway.
Tesamorelin has been tested in more than 800 HIV-positive people in well-designed clinical trials. Many participants used tesamorelin for between six and 12 months. This usually resulted in a significant decrease in belly fat compared to placebo (fake tesamorelin). There was a small increase in muscle mass among tesamorelin users and no loss of subcutaneous fat. Levels of triglycerides, a fatty substance in the blood, decreased modestly among tesamorelin users.
3.Applications:
Tesamorelin injection comes as a powder to be mixed with the liquid provided with your medication and injected subcutaneously (under the skin). It is usually injected once a day. Use tesamorelin injection at around the same time every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand.
Before you use tesamorelin injection for the first time, read the manufacturer's information for the patient that comes with the medication. Your medication comes in 2 boxes: one box with tesamorelin injection vials and another with vials containing liquid to mix with the medication, needles, and syringes.
Tesamorelin is an analogue of GHRH (releasing hormone, a naturally-occurring peptide released from the hypothalamus) that was recently approved by the FDA for treatment (reduction) of HIV-induced lipodystrophy-related visceral fat and is now marketed under the trade name Egrifta. Like GHRH, tesamorelin exerts its effects through inducing GH release from the pituitary.
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