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1.Quick View:
Product Name: Gonadorelin
CAS: 33515-09-2
Purity (HPLC): 98.0%min.
Appearance: White powder
MF: C55H75N17O13
MW: 1182.29
Usage: Mainly used for prostate cancer.
Applications :Gonadorelin (the naturally occurring form of lHrH, also known as GnrH) is used in controlling the ovulation of women with decreased fertility and is, furthermore, used extensively for veterinary purposes, particularly in the cattle industry.
2.Description:
Gonadorelin is used by women who are missing menstrual periods due to low levels of gonadotropin-releasing hormone (GnRH). It may be used as part of female infertility treatment. This medication provides GnRH that the body needs for the growth and release of mature eggs from the ovaries (ovulation).
Gonadotropin releasing hormone secretion induces acute release of luteinizing hormone and follicle stimulating hormone. The pulsatile pattern of LH secretion from the pituitary is determined by GnRH neurons in the hypothalamus and the preoptic area of the forebrain. During estrus, high estradiol concentrations stimulate GnRH release; this induces LH synthesis, secretion, and, ultimately, an LH surge that results in ovulation. Estradiol and progesterone influence neurons involved in GnRH and LH release . In addition, LH receptor mRNA is expressed on granulosa cells when the dominant follicle is greater than 9 mm in diameter. These control mechanisms account for the variation in ovulatory response to a GnRH treatment given at different stages of the estrous cycle .
3.Applications:
Gonadotropin-releasing hormone, also known as follicle-stimulating hormone-releasing hormone or luteinizing hormone-releasing hormone, is peptide hormone responsible for stimulating the anterior pituitary to release follicle-stimulating hormone and luteinizing hormone. GnrH is considered the initial step of the hypothalamic-pituitary-gonadal axis.
At the pituitary, GnRH stimulates the synthesis and secretion of the gonadotropins, follicle-stimulating hormone , and luteinizing hormone. These processes are controlled by the size and frequency of GnRH pulses, as well as by feedback from androgens and estrogens. Low-frequency GnRH pulses are required for FSH release, whereas high-frequency GnRH pulses stimulate LH pulses in a one to one manner.
GnRH is secreted in the hypophysial portal bloodstream at the median eminence.The portal blood carries the GnRH to the pituitary gland, which contains the gonadotrope cells, where GnRH activates its own receptor, gonadotropin-releasing hormone receptor , a seven-transmembrane G-protein-coupled receptor that stimulates the beta isoform of Phosphoinositide phospholipase C, which goes on to mobilize calcium and protein kinase C. This results in the activation of proteins involved in the synthesis and secretion of the gonadotropins LH and FSH. GnRH is degraded by proteolysis within a few minutes.
