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ACE-031
ACVR2B (ACE-031) has to be the coolest and strangest thing out there. It is a monoclonal antibody genetically engineered to bind to myostatin before myostatin can bind to its receptor and stop muscle growth. Ace-031, also known as ACVR2B, is a soluble form of activin type IIB receptor, which is an inhibitor of myostatin and other naturally occurring proteins that limit muscle growth. This compound was genetically developed to bind to myostatin before it can attach to its receptor and halt muscle growth. The two Biopharma companies that worked on this compound are Acceleron and Shire.
Fat loss and bone health
In the different studies that were conducted, subjects experienced a reduction in leptin concentration and boosted adiponectin, which is a 'good fat' hormone. Hence, perhaps Ace-031 does really contribute to fat loss. Another study showed an increase in alkaline phosphatase in the blood and reduced collagen telopeptide; this may mean it also helps strengthening the bones.
What is myostatin and why do bodybuilders want to stop it?
Myostatin is a hormone in our bodies that signals muscles to stop growing and replicating. Therefore, when you inhibit, or block myostatin, muscles will be able to grow bigger and you will become stronger. Imagine being able to block myostatin and continue to grow muscle indefinitely - you would be able to become like a super hero.
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