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CAS 67392-87-4 Drospirenone
What is Drospirenone?
Drospirenone
is a progestin medication which is used in birth control pills and in
menopausal hormone therapy. The medication is available only in combination
with an estrogen.
Drospirenone is a synthetic progestin that is an analog to spironolactone. It
is found in a number of birth control formulations. Drospirenone differs from
other synthetic progestins in that its pharmacological profile in preclinical
studies shows it to be closer to the natural progesterone. As such it has
anti-mineralocorticoid properties, counteracts the estrogen-stimulated activity
of the renin-angiotensin-aldosterone system, and is not androgenic. It was
shown in animal studies that drospirenone exhibits antiandrogenic activity
judging from accessory sex gland growth in castrated, androgen-treated,
juvenile rats.
