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Dutasteride
Alias: Avodart ; Duagen
CAS NO: 164656-23-9
MF: C27H30F6N2O2
MW: 528.53
Purity: 99%
Appearance:white powder.
Mechanism of action:
Dutasteride belongs to a class of drugs called 5-alpha-reductase inhibitors, which block the action of the 5-alpha-reductase enzymes that convert testosterone into dihydrotestosterone (DHT).
Dutasteride versus finasteride:
Finasteride is also approved for the treatment of benign prostatic hyperplasia, or BPH. The medications belong to the same class of drugs.
Dutasteride inhibits two of the three isoforms of 5-alpha reductase, I and II, whereas finasteride only inhibits type II, and has a much shorter half-life.Bexlosteride is an isoform I selective inhibitor, albeit with limited commercial availability.
Chemical synthesis:
Dutasteride can be synthesized from 3-oxoandrost-4-ene-17-carboxylic acid
Applications:
Dutasteride is useful for treating benign prostatic hyperplasia (BPH); colloquially known as an "enlarged prostate".
In those who are being regularly screened, 5-alpha-reductase inhibitors such as finasteride and dutasteride reduce the overall risk of being diagnosed with prostate cancer; however, there is insufficient data to determine if they have an effect on the risk of death and may increase the chance of more serious cases.
Specifications:
|
Test Items |
Specification |
Test Results |
|
Description |
White or almost white powder |
Complies |
|
Identification |
Meet the requirements |
Complies |
|
Loss on drying |
≤0.5% |
0.2% |
|
Melting range |
246℃~252℃ |
246℃~248℃ |
|
Heavy metals |
≤20ppm |
Complies |
|
Residue on ignition |
≤0.1% |
Complies |
|
Related substances |
Biggest Impurities≤0.5% |
0.36% |
|
Total Impurity≤1.0% |
0.7% |
|
|
Assay |
97.0%~103.0% |
99.3% |
|
Conclusion |
Complies with In-house Standard |
|
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