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High Putiry Pharm Raw Powder Amstat Tranexamic Acid
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Tranexamic acid
CAS: 1197-18-8
Molecular Weight: 157
Molecular Formula: C8H15NO2
Assay: 99-101%
Packing: 25kg / carton
Appearance: White crystalline powder
The applications:
Hemostatic, anti-allergic, anti-inflammatory effect
Usage:
1. Hemostatic, significant effect on traumatic bleeding, preoperative prophylactic medication can decrease operation hemorrhage.
2. The chemical structure of tranexamic acid and lysine, competitive inhibition of plasminogen to fibrin adsorption, to prevent their activation, protect the fiber protein was not degraded by the enzyme and dissolved, ultimately achieve hemostasis effect.
3. All applicable in the treatment of acute or chronic, localized or systemic primary fibrinolysis hyperfunction caused by bleeding, such as obstetric hemorrhage, renal hemorrhage, hypertrophy of the prostate, hemophilia hemorrhage, pulmonary tuberculosis hemoptysis, bleeding in the stomach, liver, lung, spleen and other organs of hemorrhage after operation
4. The clinical effect of tranexamic acid on insect bites, eczema and dermatitis, simple purpura, chronic urticaria, artificial sex urticaria, rash and drug poisoning effect, also have certain effects on erythroderma, scleroderma, SLE, erythema multiforme, herpes zoster and alopecia areata, curative effect of hereditary angioedema is also good.
Application:
The development and fibrinolytic phenomena associated with the body heal under physiological or pathological state of fibrinolysis, increased vascular permeability, etc., but also on the body caused by reaction with fibrinolysis, a variety of symptoms and allergic reactions such as bleeding. This product can inhibit plasmin, and display bleeding, anti-allergic, anti-inflammatory effect.
The role of an anti-plasmin in
Tranexamic acid can be combined with the plasmin and plasminogen and fibrin affinity site lysine site (LBS) is strongly adsorbed by inhibition of plasmin, plasminogen and fibrin binding and thus strongly inhibit fibrin by plasmin-induced decomposition; Addition, in the presence of serum and other anti-plasmin macroglobulin, tranexamic acid antifibrinolytic effect is more obvious.
Tranexamic Acid Specification:
Items Tested |
Specification | BP2007 | Result |
| Characteristics | White or almost white, crystalline powder | White crystalline powder | |
| Melting point | More than 300 degree | Conforms | |
| Identification | Infrared absorption atlas consistent with the contrast atlas | Conforms | |
| Solubility | Soluble in water, practically insoluble in acetone and alcohol | Conforms | |
| Clarity and color | Solution should clarify and colorless | Conforms | |
| PH value | 7.0_8.0 | 7.3 | |
| Related substances Liquid chromatography |
Impurity A: not more than 0.1% Impurity B: not more than 0.2% Impurity C: not more than 0.1% Impurity D: not more than 0.1% |
0 0.10% 0.01% 0.01% |
|
| Loss on drying | Not more than 0.5% | 0.20% | |
| Sulphate | Not more than 0. 07% | 0.01% | |
| Chloride | Not more than 140ppm | Less than 140ppm | |
| Heavy metals | Not more than 10ppm | Less than 10ppm | |
| Residue on Ignition | Not more than 0.1% | 0.02% | |
| Assay (HPLC) | ≥99.0% | 99.68% | |
| Conclusion | Conforms BP2007 | ||
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