RSPO3 Antibody;FITC conjugated

Product Name: RSPO3 Antibody;FITC conjugated

Code : CSB-PA887150LC01HU

Immunogen : Recombinant human R-spondin-3 protein

Raised in : Rabbit

Species Reactivity : Human

Tested Applications : ELISA,WB,IHC

Relevance : Activator of the canonical Wnt signaling pathway by acting as a ligand for LGR4-6 receptors. Upon binding to LGR4-6 (LGR4, LGR5 or LGR6), LGR4-6 associate with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. Also regulates the canonical Wnt/beta-catenin-dependent pathway and non-canonical Wnt signaling by acting as an inhibitor of ZNRF3, an important regulator of the Wnt signaling pathway. Acts as a ligand for frizzled FZD8 and LRP6. May negatively regulate the TGF-beta pathway.

Form : Liquid

Conjugate : FITC

Alias : R-spondin-3,RSPO3,PWTSR,THSD2,Protein with TSP type-1 repeat,hPWTSR,Roof plate-specific spondin-3,hRspo3,Thrombospondin type-1 domain-containing protein 2