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Description:
CAS |
189691-06-3 |
| SYNONYMS | PT-141, Bremelanotide |
| SEQUENCE | Ac-Nle-cyclo(Asp-His-D-Phe-Arg-Trp-Lys-OH) |
| CHEMICAL NAME | NA |
| MOLECULAR FORMULA | C50H68N14O10 |
| MOLECULAR WEIGHT | 1025.16 |
| PURITY | ≥98% (HPLC) |
| PHYSICAL STATE | Lyophilized Powder |
| SOLUBILITY | Soluble in water or 1% acetic acid |
| STORAGE | Lyophilized peptides although stable at room temperature for 3 months, Should be stored desiccated below -18°C.Upon reconstitution of the peptids It should be stored at 4°C between 2-21 days and for future use below -18°C. |
PT-141, the first in a new class of therapies called melanocortin agonists, works through a mechanism of action involving the central nervous system rather than directly on the vascular system.As a result,it may offer significant safety and efficacy benefits over currently available products, which belong to the class of phosphodiesterase-5 (PDE-5) inhibitors.
PT-141 is nasally administered and is both non-invasive and fast acting.importantly, PT-141 is not expected to be contraindicated in patients taking nitrates for the treatment of cardiovascular disease.Clinical studies have demonstrated PT-141 to be safe and effective and to improve patient experience.
Application:
PT-141 or Bremelanotide is the generic term for a research peptide being studied for its possible use in helping to improve sexual dysfunction in both men (erectile dysfunction or impotence) and women (sexual arousal disorder).PT-141 was developed from the tanning peptide Melanotan 2, which is a synthetically produced variant of a peptide hormone naturally produced in the body that stimulates melanogenesis that is known as alpha-Melanocyte stimulating hormone.MSH, activates certain melanocortin receptors in the process of exerting its effects.Indeed, MSH also exerts potent influence over lipid metabolism, appetite, and sexual libido.
Resultantly, PT-141 has been shown in studies to exhibit libido-enhancing effects by activating the melanocortin receptors MC1R and MC4R, but not skin tanning.Melanotan 1 and Melanotan 2 have been researched for their use in protecting against the harmful effects of ultraviolet radiation from sunlight due to their melanogenesis-stimulating properties.
Usage:
PT-141 is a potential remedy for the treatment of sexual dysfunction;Specifically, male erectile dysfunction.Studies have shown that PT-141 does not act on the vascular system like former compounds, but allegedly works by activating melanocortin receptors in the brain, therefore helping increase ones sexual stimulation.
PT-141 is a melanocortin based peptide that has shown effectiveness in clinical studies on both male and female rats.Male rats have shown erectile response with doses as low as 1-2 mgs whereas most female rats have shown positive results with higher doses around 2-3 mgs.While the dosage requirements tend to be higher for female rats, the observable results in female rats tend to be stronger.
COA:
| Assay(By HPLC) | 95% ~105% | 98.9% |
| Appearance | White powder | White powder |
| Solubility | Soluble in water or 10% acetic acid to give a clear, colorless solution | Conforms |
| Amino Acid Composition | ±10% of theoretical | Conforms |
| Related Substance(By HPLC) | Total Impurities(%) 3.0% Largest Single Impurity(%) 1.0% | 1.1% 0.3% |
| Acetate Content(By HPLC) | 15.0% | 8.0% |
| Water Content(Karl Fischer) | <8.0% | 3.5% |
| Peptide content(N determination) | ≥80.0% | 87.8% |
| Bacterial Endotoxins | < 5 EU/mg | Conforms |
| Peptide Putity(By HPLC) | ≥97% by area integration | 98.9% |
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| Gonadorelin | 2mg/vial,10vials/kit |
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| Selank | 5mg/vial,10vials/kit |
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