Dutasteride

Dutasteride
Dutasteride CAS: 164656-23-9
Dutasteride MF: C27H30F6N2O2
Dutasteride MW: 528.53
Dutasteride mp  242-250°C
Dutasteride storage temp -20°C Freezer
Dutasteride is white crystalline solid.
Dutasteride helps prevent hair loss.
Dutasteride is used in the treatment of benign prostatic hyperplasia. Dual inhibitor of 5a-reductase isoenzymes type 1 and 2; structurally related to Finasteride.
Dutasteride is antihypertensive, ACE inhibitor.

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Dutasteride is a white to pale yellow powder with a melting point of 242° to 250°C. It is soluble in ethanol (44 mg/mL), methanol (64 mg/mL), and polyethylene glycol 400 (3 mg/mL), but it is insoluble in water.

Dutasteride (Avodart), is a dual 5-α reductase inhibitor that inhibits conversion of testosterone to dihydrotestosterone (DHT). It is used to treat benign prostatic hyperplasia.

Brand names
Avodart
Brand names of combination products
Jalyn(containing Dutasteride, Tamsulosin)

DUTASTERIDE WARNINGS
Dutasteride should be used with caution in: mild to moderate liver disease, patients who are about to have a blood test for prostate-specific antigen (PSA).

It should not be used in: children, adolescents, women, patients who are allergic to dutasteride, other 5-alpha reductase inhibitors, or to any other ingredients in the medicine, severe liver disease.

STORAGE
Do not store above 30ºC.

Dutasteride is used for:
Treating symptoms of benign prostatic hyperplasia (BPH) or enlargement of the prostate gland. It also helps to reduce the risk of urinary blockage and the need for surgery to treat BPH. It may be used alone or along with another medicine (tamsulosin).

Dutasteride is a 5 alpha-reductase enzyme inhibitor. It works by lowering levels of a hormone called dihydrotestosterone (DHT), which is a major cause of prostate growth. Lowering DHT leads to shrinkage of the enlarged prostate gland.

Uses
This medication is used in men to treat the symptoms of an enlarged prostate (benign prostatic hyperplasia-BPH). It works by reducing the size of the enlarged prostate. This helps to relieve symptoms of BPH such as difficulty in beginning the flow of urine, weak stream, and the need to urinate frequently or urgently (including during the middle of the night). It may also reduce the need for surgery to treat BPH.

Dutasteride is not approved for prevention of prostate cancer. It may slightly increase the risk of developing a very serious form of prostate cancer.

Dutasteride is chemically designated as (5α,17β)-N-{2,5 bis(trifluoromethyl)phenyl}-3oxo-4-azaandrost-1-ene-17-carboxamide. The empirical formula of dutasteride is C27H30F6N2O2, representing a molecular weight of 528.5 with the following structural formula:

AVODART is a synthetic 4-azasteroid compound that is a selective inhibitor of both the type 1 and type 2 isoforms of steroid 5 alpha-reductase, an intracellular enzyme that converts testosterone to DHT.

Medical uses
Dutasteride is useful for treating benign prostatic hyperplasia (BPH); colloquially known as an "enlarged prostate".

Mechanism of action
Dutasteride belongs to a class of drugs called 5-alpha-reductase inhibitors, which block the action of the 5-alpha-reductase enzymes that convert testosterone into dihydrotestosterone (DHT).

Dutasteride versus finasteride
Finasteride is also approved for the treatment of benign prostatic hyperplasia, or BPH. The medications belong to the same class of drugs.
Dutasteride inhibits two of the three isoforms of 5-alpha reductase, I and II, whereas finasteride only inhibits type II, and has a much shorter half-life.