Tibolone

Tibolone
Tibolone alias: Livial
Tibolone CAS: 5630-53-5
Tibolone MF: C21H28O2
Tibolone MW: 312.45  
Tibolone EINECS: 227-069-1
Tibolone mp 169 °C
Tibolone storage temp 2-8°C
Tibolone refractive index  105 ° (C=0.54, CH2Cl2/Et2O)
Tibolone is a synthetic steroid with weak estrogenic, androgenic and progestogenic activity.
Tibolone is a pharamceutical used in the treatment of menopausal syndrome

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Tibolone (Livial) is a hormone therapy registered for the treatment of menopausal symptoms and the prevention of osteoporosis. It was first introduced in 1988 and is currently available in 90 countries. The main safety variable of LIBERATE (Livial Intervention Following Breast Cancer; Efficacy, Recurrence and Tolerability Endpoints) was to show that Livial does not increase the risk of breast cancer recurrence compared to placebo in patients with menopausal symptoms and a history of breast cancer (ie, non-inferiority). At the close of randomization in December 2004, a total of 3148 subjects (randomly assigned in a blind fashion to either Livial or placebo) had been enrolled in the study, at 245 sites in 31 countries in Europe, Asia, Australia and Latin America.

Tibolone

UK matches:

TIBOLONE 2.5 MG TABLETS (Leaflet)
TIBOLONE 2.5MG TABLETS (Leaflet)
Scheme

Rec.INN

ATC (Anatomical Therapeutic Chemical Classification)

G03CX01,G03DC05

CAS registry number (Chemical Abstracts Service)

0005630-53-5

Chemical Formula

C21-H28-O2

Molecular Weight

312

Therapeutic Categories

Hormone replacement therapy (HRT)

Synthetic steroid with partial estrogenic, progestagenic and androgenic activity

Chemical Name

19-Norpregn-5(10)-en-20-yn-3-one, 17-hydroxy-7-methyl-, (7α,17α)-

Foreign Names

Tibolonum (Latin)
Tibolon (German)
Tibolone (French)
Tibolona (Spanish)
Generic Names

Tibolone (OS: USAN, DCF, BAN)
Org OD 14 (IS)
Tibolone (PH: BP 2011, Ph. Eur. 7)
Tibolonum (PH: Ph. Eur. 7)
Brand Names

Boltin
Organon, Spain
Bontil
Probiomed, Mexico
Cervictal
Monte, Argentina
Climafem
Andromaco, Chile
Climatix
Investi, Argentina
Clitax
Tecnimede, Portugal
Discretal
Beta, Argentina
Femenil A
Medco, Peru
Femsel
Elmor, Venezuela
Fomene
Leti, Venezuela
Goldar
Pentafarma, Portugal
Heria
Mithra, Belgium
Ladybon
Zentiva, Bulgaria; Zentiva, Czech Republic; Zentiva, Lithuania; Zentiva, Latvia; Zentiva, Poland; Zentiva, Romania; Zentiva, Russian Federation
Libiam
Libbs, Brazil
Libron
Myung Moon, South Korea
Lirex
Silesia, Chile
Livial D.A.C.
DAC, Iceland
Livial
Merck Sharp & Dohme, China; Merck Sharp & Dohme, United Kingdom; MSD, Switzerland; MSD, Sweden; MSD France, France; Organon, Belgium; Organon, Bulgaria; Organon, Bahrain; Organon, Brazil; Organon, Czech Republic; Organon, Denmark; Organon, Estonia; Organon, Greece; Organon, Hong Kong; Organon, Hungary; Organon, Indonesia; Organon, Ireland; Organon, Israel; Organon, India; Organon, Iceland; Organon, Italy; Organon, South Korea; Organon, Lithuania; Organon, Latvia; Organon, Malta; Organon, Mexico; Organon, Malaysia; Organon, Netherlands; Organon, Norway; Organon, Oman; Organon, Peru; Organon, Philippines; Organon, Poland; Organon, Portugal; Organon, Romania; Organon, Serbia; Organon, Russian Federation; Organon, Singapore; Organon, Slovenia; Organon, Slovakia; Organon, Thailand; Organon, Venezuela; Schering-Plough, Australia; Schering-Plough, Chile; Schering-Plough, Colombia; Schering-Plough, Costa Rica; Schering-Plough, Dominican Republic; Schering-Plough, Finland; Schering-Plough, Guatemala; Schering-Plough, Honduras; Schering-Plough, Croatia (Hrvatska); Schering-Plough, Nicaragua; Schering-Plough, New Zealand; Schering-Plough, Panama; Schering-Plough, El Salvador; Schering-Plough, Turkey; Schering-Plough, Taiwan
Liviel
Organon, Austria
Liviella
Merck Sharp & Dohme, Germany
Livifem
Adcock Ingram Pharmaceuticals, South Africa
Livolon
Biolab, Brazil
Menorest
Renata, Bangladesh; Renata, Philippines
Menotibol
MK, Colombia
Menotrix
Medicamenta Ecuatoriana, Ecuador
Menox
Roddome, Ecuador
Neotilom
AC Farma, Peru
Paraclim
Elea, Argentina
Qi Luo Shu
Youhua Pharmaceutical, China
Reduclim
Farmoquimica, Brazil
Senalina
Omega, Argentina
Sintemel
Asofarma, Guatemala; Asofarma, Honduras; Asofarma, Nicaragua; Asofarma, El Salvador
Tibelox
Gynocare Limited, Vietnam
Tiboclim
Panalab, Argentina
Tibofem
Cipla, India; Organon, Argentina
Tibolon Orifarm
Orifarm Generics, Sweden
Tibolona
Genamerica, Ecuador; Monte, Argentina
Tibolone - Zizhu
Zizhu, China
Tibolone Teva
Teva, Lithuania; Teva, Latvia
Tibolux
Hospimedikka, Ecuador; Refasa, Peru
Tibomax
Sherfarma, Peru
Tibona
ABL Pharma, Peru
Tibonella
Chalver, Colombia; Chalver, Ecuador
TiboTeva
Teva, Poland
Tinox
Farmindustria, Peru; Gynopharm, Chile; Gynopharm, Colombia; Vivax, Venezuela
Tirovarina
Biol, Argentina
Tobe
Chile, Chile
Tocline
Rontag, Argentina
Ubilon
Incepta, Bangladesh
Xyvion
British Pharmaceuticals, Australia