Exemestane CAS:107868-30-4

 Anti-estrogen Steroids Powder Exemestane CAS:107868-30-4

1. Quick Detail

CAS:107868-30-4
Product Category: Pharmaceutical raw materials and intermediates
Product content: ≥ 99%
Molecular formula: C20H24O2
Molecular Weight:296.40
Molecular Structure:
 
Packing specifications: 25kg / barrel
Appearance: White or Almost White Crystalline Powder
Usage:This product is an adrenal cortical hormone drugs. A variety of pharmacological effects of anti-inflammatory, anti allergic and immune suppression.

2. Product Description

Exemestane is an oral steroidal aromatase inhibitor that is used in ER-positive breast cancer in addition to surgery and/or radiation in post-menopausal women.
The main source of estrogen is the ovaries in premenopausal women, while in post-menopausal women most of the body's estrogen is produced via the conversion of androgens into estrogen by the aromatase enzyme in the peripheral tissues (i.e. adipose tissue like that of the breast) and a number of sites in the brain. Estrogen is produced locally via the actions of the aromatase enzyme in these peripheral tissues where it acts locally. Any circulating estrogen in post-menopausal women as well as men is the result of estrogen escaping local metabolism and entering the circulatory system.

3. Applications

Exemestane is an irreversible, steroidal aromatase inactivator, structurally related to the natural substrate androstenedione. It acts as a false substrate for the aromatase enzyme, and is processed to an intermediate that binds irreversibly to the active site of the enzyme causing its inactivation, an effect also known as "suicide inhibition." By being structurally similar to enzyme targets, Exemestane permanently binds to the enzymes, preventing them from converting androgen into estrogen.

Exemestane is taken in tablet form once a day. Patients can experience side effects like nausea, anxiety, shortness of breath, abdominal pain, bone pain, and chest pain. Side effects vary widely between patients and patients should report the side effects they experience to their doctors, as some may be indicators of dangerous complications. Shortness of breath and chest pain in particular are causes for concern in patients taking exemestane.
 

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