Dexamethasone

Synonyms: 16alpha)-9-fluoro-11,17,21-trihydroxy-16-methylpregna-1,4-diene-3,20-(11bet

CAS: 050-02-2 

Molecular formula: C22H29F05 

MW: 392.46 

EINECS: 200-230-3 

Melting point: 262-264°C 

Assay:98%

Density:  1.32 g/cm3

Boiling Point:  568.2 °C at 760 mmHg

Flash Point:  297.5 °C

Packing: 5KG/TIN,2TIN/CTN 

Unit: KG 

Quality Standards: CP2005/USP/BP/EP 

Chemical Properties: White Crystalline Solid

Usage: A glucocorticoid anti-inflammatory agent. Regulates T cell survival, growth, and differentiation. Inhibits the induction of nitric oxide .As an anti-inflammatory medication.  Dexamethasone Acetate relieves inflammation in various parts of the body.  It is used specifically to decrease swelling (edema), associated with tumors of the spine and brain, and to treat eye inflammation.

Dexamethasone Acetate is used To treat or prevent allergic reactions.

Dexamethasone Acetate is also used To treat nausea and vomiting associated with some chemotherapy drugs.

Dexamethasone Acetate used to replac steroids in conditions of adrenal insufficiency

As treatment for a variety of cancers, such as leukemia, lymphoma, and multiple myeloma.  

As treatment of certain kinds of autoimmune diseases, skin conditions, asthma and other lung conditions.

Dexamethasone Acetate to stimulate appetite in cancer patients with severe appetite problems.

Applications:

Dexamethasone, a corticosteroid, is similar to a natural hormone produced by your adrenal glands. It often is used to replac this chemical when your body does not make enough of it. It relieves inflammation (swelling, heat, redness, and pain) and is used to treat certain forms of arthritis; skin, blood, kidney, eye, thyroid, and intestinal disorders (e.g., colitis); severe allergies; and asthma. Dexamethasone is also used to treat certain types of cancer.

Dexamethasone comes as a tablet and a solution to take by mouth. Your doctor will prescribe a dosing schedule that is best for you. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take dexamethasone exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.

Do not stop taking dexamethasone without talking to your doctor. Stopping the drug abruptly can cause loss of appetite, upset stomach, vomiting, drowsiness, confusion, headache, fever, joint and muscle pain, peeling skin, and weight loss. If you take large doses for a long time, your doctor probably will decrease your dose gradually to allow your body to adjust before stopping the drug completely. Watch for these side effects if you are gradually decreasing your dose and after you stop taking the tablets or oral liquid, even if you switch to an inhalation corticosteroid medication. If these problems occur, call your doctor immediately. You may need to increase your dose of tablets or liquid temporarily or start taking them again.

1. Principle

This test kit is based on the competitive enzyme immunoassay for the detection of Dexamethasone in the sample. The coupling antigen is pre-coated on the micro-well stripes. The Dexamethasone in the sample and the coupling antigen pre-coated on the micro-well stripes compete for the anti-Dexamethasone antibody. After the addition of the enzyme conjugate, the TMB substrate is added for coloration. The optical density (OD) value of the sample has a negative correlation with the Dexamethasone in it. This value is compared to the standard curve and the Dexamethasone concentration is subsequently obtained.

2. Technical specifications

Sensitivity: 0.1ppb

Incubation Temperature: 25℃

Incubation Time:30min～15min

Detection limit:

Tissue............................................................................................ 0.1 ppb

Feed.............................................................................................. 0.2 ppb

Milk powder.................................................................................... 0.3 ppb

Milk................................................................................................ 0.2 ppb

Honey............................................................................................ 0.2 ppb

Urine.............................................................................................. 0.2 ppb

Cross-reaction rate:

Dexamethasone................................................................................. 100%

Recovery rate

Tissue, feed................................................................................... 90±25%

Milk powder.................................................................................... 85±25%

Urine, milk, honey…………………………………………………………. 95±25%

3. Components

Micro-well strips: 12 strips with 8 removable wells each

6× standard solution (1 mL each): 0 ppb, 0.1 ppb, 0.3 ppb, 0.9 ppb, 2.7 ppb and 8.1 ppb

Enzyme conjugate (7 mL)................................................................red cap

Antibody working solution (7 mL)......................................................blue cap

Substrate A solution (7 mL)..........................................................white cap

Substrate B solution (7 mL)...........................................................black cap

Stop solution (7 mL)..................................................................yellow cap

20× concentrated washing buffer (15 mL)..............................................white cap

5× concentrated redissolving solution (110 mL).......................................transparent cap