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Quick Detail:
Tadalafil is a PDE5 inhibitor marketed in pill form for treating erectile dysfunction (ED) under the name Cialis, and under the name Adcirca for the treatment of pulmonary arterial hypertension.
Description:
Tadalafil Citrate
Alias: Tadalafei;Cialis
CAS No: 171596-29-5
MF: C22H19N3O4
MW: 389.41
Purity: 99.5%
Appearance: white powder, odorless, tasteless, insoluble in water and alcohol.
Applications:
Although sildenafil (Viagra), vardenafil (Levitra), and tadalafil (Cialis) all work by inhibiting PDE5, tadalafil's pharmacologic distinction is its longer half-life (17.50 hours) – compared to sildenafil (4.0–5.0 hours) and vardenafil (4.0–5.0 hours) – resulting in longer duration of action, and so partly responsible for "The Weekend Pill" sobriquet. Furthermore, the longer half-life is the basis for current investigation of tadalafil's daily therapeutic use in relieving pulmonary arterial hypertension. Sildenafil is approved in several world regions as a thrice-daily therapy for pulmonary arterial hypertension.
Specifications:
|
Test Items |
Specification |
Test Results |
|
Appearance |
White powder |
Conforms |
|
Test method |
High pressure liquid chromatography(HPLC) |
Conforms |
|
Melting Point |
300℃～303℃ |
301.5℃-302.6℃ |
|
Loss on drying |
≤0.5% |
0.24% |
|
Heavy metals(Pb) |
≤20ppm |
7.5ppm |
|
Residue on ignition |
≤0.1% |
0.08% |
|
Relative substance |
≤1.0% |
0.145% |
|
Assay (on dried basis) |
≥98.5% |
99.33% |
|
Conclusion |
The product conform to USP 32. |
|
Competitive Advantage:
1. Rich experience
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