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| Product name | Altrenogest |
| Synonym | 11-trien-3-one,17-alpha-allyl-17-hydroxy-estra-9;17-allyltrenbolone;17-alpha-allyl-estratriene-4,9,11,17-beta-ol-3-one;17-hydroxy-17-(2-propenyl)-(17-beta)-estra-11-trien-3-one;drc6246;r2267;ru2267;Allyltrenbolone |
| CAS Registry Number | 850-52-2 |
| Assay | 99% |
| Molecular Formula | C21H26O2 |
| Molecular Weight | 310.43 |
| Appearance | Light yellow crystal or powder |
Description:
Progestins are primarily produced endogenously by the corpus luteum. They transform proliferative endometrium to secretory endometrium, enhance myometrium hypertrophy and inhibit spontaneous uterine contraction. Progestins have a dose-dependent inhibitory effect on the secretion of pituitary gonadotropins and also have some degree of estrogenic, anabolic and androgenic activity.
Altrenogest (or allyltrenbolone) is a synthetic trienic C21 steroidal progestomimetic, belonging to the 19-nor-testosterone series. It is an orally active (pro)gestagen. Like all steroids, altrenogest acts by its liposolubility by penetrating the target cells where it binds to specific receptors.
Applications:
The pharmacodynamic activity of altrenogest has been demonstrated in a number of animal models. The most important effects are the progestomimetic and anti-gonadotrophic effects. Altrenogest also has weak oestrogenic, anabolic and androgenic effects, but has no corticoid or anti-inflammatory effects.
Altrenogest is indicated (labeled) to suppress estrus in mares to allow a more predictable occurrence of estrus following withdrawal of the drug. It is used clinically to assist mares to establish normal cycles during the transitional period from anestrus to the normal breeding season often in conjunction with an artificial photoperiod. It is more effective in assisting in pregnancy attainment later in the transition period. One group of authors (Squires et al. 1983) suggest selecting mares with considerable follicular activity (mares with one or more follicles 20 mm or greater in size) for treatment during the transitional phase. Mares that have been in estrus for 10 days or more and have active ovaries are also considered to be excellent candidates for progestin treatment.
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