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1. Quick Details:
Exemestane
Alias: Aromasin ; Exemestan;Exemestane
Product Category: Pharmaceutical raw materials and intermediates
Assay: 98%min
CAS Registry Number:107868-30-4
Molecular formula: C20H24O2
Molecular Weight:296.40
Appearance: White or Almost White Crystalline Powder
Grade : Pharmaceutical Grade
Storage: Shading, confined preservation
Manufacturer :SUPER STEROIDS
Delivery time :within 18 hours upon receipt of payment
Delivery: EMS, DHL, TNT, FedEx, UPS
Usage: Developed to help fight breast cancer, Aromasin is one of the most powerful estrogen suppressing compounds
Other drugs in same class:Anastrozole,Letrozole,Tamoxifen citrate,Exemestane
2. Product Description:
|
TEST ITEMS |
SPECIFICATION |
RESULTS |
|
Description |
: White Crystalline Powder |
White Powder |
|
Identification |
: Positive |
Positive |
|
Assay(by HPLC) |
: 98.0~102.0% |
98.64% |
|
Absorbance(E1cm) |
: 465~495 |
482.5 |
|
Melting Point |
: 191~195°C |
193.5~195.0°C |
|
Loss On Drying |
: 0.5%max |
0.19% |
|
Specific Rotation |
: +288°~ +298° |
+290.2° |
|
Residue On Ignition |
: 0.1%max |
0.03% |
|
Related Substances |
: Total:1.5%max |
<1.3% |
|
Single:0.5%max |
<0.4% |
|
|
Residue Solvents |
: 0.2%max |
0.10% |
|
Heavy metals |
: 20PPm max |
<10PPm |
|
Conclusion |
The specification conform with enterprise standard. |
|
3. Applications:
Exemestane is an oral steroidal aromatase inhibitor that is used in ER-positive breast cancer in addition to surgery and/or radiation in post-menopausal women.
The main source of estrogen is the ovaries in premenopausal women, while in post-menopausal women most of the body's estrogen is produced via the conversion of androgens into estrogen by the aromatase enzyme in the peripheral tissues (i.e. adipose tissue like that of the breast) and a number of sites in the brain. Estrogen is produced locally via the actions of the aromatase enzyme in these peripheral tissues where it acts locally. Any circulating estrogen in post-menopausal women as well as men is the result of estrogen escaping local metabolism and entering the circulatory system.
