Pirfenidone CAS 53179-13-8

Pirfenidone   CAS 53179-13-8

Synonym:Pirfenidone;amr-69; amr69;Esbriet;5-Methyl-1-phenyl-2-(1H)-pyridone

MW: 185.22

MF : C12H11NO

Category:Antiinflammatory Agents

Solubility:H2O: >10 mg/mL at 60 °C (warming for 30 minutes);DMSO: >20 mg/mL

Min order: 10grams

Quality standard : Enterprise standard

Place of Origin:China

Appearance:White crystal powder

Melting Point:102--109°C

Loss on drying:<1.0%

Known single impurity:<1.0%

Unknown single impurity:<0.5%

Total impurity:<2.0%

Assay(as dried):99%

Type:Analysis reagent

Application: Esbriet (pirfenidone) is an anti-inflammatory drug used to treat idiopathic pulmonary fibrosis.Antifibrotic agent, effective in models of pulmonary and lung fibrosis. Inhibits collagen production and fibroblast proliferation. Regulates cytokine levels following oral administration in vivo. Potent scavenger of free radicals and inhibitor of lipid peroxidation.Pirfenidone inhibits collagen production and fibroblast proliferation. It has shown antifibrotic and anti-inflammatory properties in variety of animal models of pulmonary fibrosis, and in clinical trials.