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But mass production availability of high-quality low-cost, good economic returns.
But mass production availability of high-quality low-cost, good economic returns.
2. Common plastic materials
Solid pharmaceutical packaging should use HDPE / PP, one-step "Note - blowing" process of production of polyolefin plastic container; filling the liquid medicine should use PET / PP "Note - pull - blow" process to produce plastic containers.
(3) processing aid and colorant
Toner bottle is usually chosen titania TiO2 (rutile or anatase), wherein the TiO2 content ≥98% Wt, the addition amount of 1.0-1.5% Wt.
Conventional lubricant processing aid, zinc stearate, polyethylene wax. It is white powder, the addition amount of 0.1-1% Wt.
In recent years, in order to meet the requirements of GMP and one hundred thousand purification, generally TiO2, zinc stearate, polyethylene wax and LDPE (high M · I) mixed together to make a masterbatch concentrate, can greatly reduce the dust pollution in the production process .
Typical TiO2 masterbatch formulation is composed as follows:
TiO2 (special grade) 60%
8% zinc stearate
Polyethylene wax 10%
LDPE 22%
For solid pharmaceutical packaging HDPE, PP is more appropriate material with excellent resistance to water vapor permeability, moisture absorption of drugs can effectively prevent deterioration. But easy to oxidative deterioration of drugs should be used with caution. LDPE poor oxygen barrier properties, not the production of pharmaceutical plastic bottles, not filling a longer shelf life of the drug. PET for water and oxygen barrier properties are excellent, and the appearance of transparency, is filling liquid medicine (syrup, oral classes) the ideal choice.
