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PharmaLegacy Laboratories (Shanghai) Co., Ltd has been devoted to study the needs of PharmaLegacy industrial customers, ant tailored to customers demand and solutions. The advantage of PharmaLegacy lies not only in the industry-leading technology and the elite professional team, but also to provide excellent services in Pharmacodynamic evaluation test platform,humanized animal model,antibody research and development servi,and the enthusiasm of positive innovation and faith of respect promise . Become a customer trusted important Rheumatoid arthritis Model integrated service providers, to help customers realize the business value of Rheumatoid arthritis Model, is PharmaLegacy unswerving mission and pursuit. Details: Rheumatoid arthritis model (RA) is a systemic inflammatory disorder characterized by chronic inflammation of the synovium, which over time results in damage to the joints, leading to pain and disability. It occurs in approximately 1% of adults, and approximately 2.5 times more women than men are affected. Immune factors involved in the progression of RA are mainly manufactured by CD4+ T cells, monocytes, macrophages, or fibroblasts. Cytokines produced by these cells such as tumor necrosis factor α (TNF-α) and interleukin-1 are the keys to the damaging cascade that ultimately triggers the production of matrix metalloproteinases and osteoclasts resulting in irreversible damage to soft tissues and bones.Understanding of molecular pathogenesis of rheumatoid arthritis model has enabled development of innovative agents to modulate specific components of the disease progress for early intervention or treatment. Various experimentally induced rheumatoid arthritis models have been used extensively as the mainstay for evaluation of those therapeutic candidates.
